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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLEK
All Species:
35.45
Human Site:
Y274
Identified Species:
78
UniProt:
P08567
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08567
NP_002655.2
350
40097
Y274
I
L
R
E
D
P
A
Y
L
H
Y
Y
D
P
A
Chimpanzee
Pan troglodytes
XP_515524
350
40124
Y274
I
L
R
E
D
P
A
Y
L
H
Y
Y
D
P
A
Rhesus Macaque
Macaca mulatta
XP_001094492
350
40060
Y274
I
L
R
E
D
P
A
Y
L
H
Y
Y
D
P
A
Dog
Lupus familis
XP_537486
375
42096
F299
V
L
R
K
D
P
A
F
L
H
Y
Y
D
P
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHK5
350
39882
Y274
I
L
R
E
D
P
A
Y
L
H
Y
Y
D
P
A
Rat
Rattus norvegicus
Q4KM33
350
39977
Y274
I
L
R
E
D
P
A
Y
L
H
Y
Y
D
P
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512767
334
37917
Y258
V
L
R
E
D
P
A
Y
L
H
Y
Y
D
P
A
Chicken
Gallus gallus
NP_990194
353
40280
Y276
V
L
R
E
D
P
A
Y
L
H
Y
Y
D
L
A
Frog
Xenopus laevis
NP_001080021
289
33430
Y219
D
N
S
E
A
L
Y
Y
F
P
D
S
G
F
F
Zebra Danio
Brachydanio rerio
NP_957135
352
40176
Y274
I
L
R
D
D
P
A
Y
I
H
Y
Y
D
P
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781827
375
42698
Y292
V
L
W
D
D
P
S
Y
L
Q
Y
Y
R
G
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
99.1
36
N.A.
92
92
N.A.
80.5
81.5
63.1
67.3
N.A.
N.A.
N.A.
N.A.
34.4
Protein Similarity:
100
100
100
55.7
N.A.
96.8
97.1
N.A.
89.4
90.6
73.7
83.8
N.A.
N.A.
N.A.
N.A.
53.3
P-Site Identity:
100
100
100
73.3
N.A.
100
100
N.A.
93.3
86.6
13.3
80
N.A.
N.A.
N.A.
N.A.
46.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
93.3
13.3
100
N.A.
N.A.
N.A.
N.A.
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
10
0
82
0
0
0
0
0
0
0
64
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
19
91
0
0
0
0
0
10
0
82
0
0
% D
% Glu:
0
0
0
73
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
10
10
0
0
0
0
10
10
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
10
10
0
% G
% His:
0
0
0
0
0
0
0
0
0
82
0
0
0
0
0
% H
% Ile:
55
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% I
% Lys:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
91
0
0
0
10
0
0
82
0
0
0
0
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
91
0
0
0
10
0
0
0
73
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% Q
% Arg:
0
0
82
0
0
0
0
0
0
0
0
0
10
0
0
% R
% Ser:
0
0
10
0
0
0
10
0
0
0
0
10
0
0
28
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
37
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
10
91
0
0
91
91
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _